| 翻訳と辞書 |
| sorting and assembly machinery ： ウィキペディア英語版 |
sorting and assembly machinery
The outer mitochondrial membrane is made up of two essential proteins, Tom40 and Sam50.
Tom40 is a protein import pore required for the import of precursor proteins across the outer mitochondrial membrane and it makes up part of the translocase of the outer membrane.
Sam50 is a subunit of the sorting and assembly machinery (SAM) of the outer membrane. The sorting and assembly machinery is a protein complex that operates after the translocase of the outer membrane, to mediate insertion of beta barrel proteins into the outer mitochondrial membrane.〔Bolender, N., Sickmann, A., Wagner, R., Meisinger, C., Pfanner, N. (2008) Multiple pathways for sorting mitochondrial precursor proteins. EMBO J 9(1): 42-49〕
==Complex components==
The sorting and assembly machinery is made up of three subunits, Sam35, Sam37 and Sam50, of which Sam50 is embedded within the outer mitochondrial membrane.〔Bolender, N., Sickmann, A., Wagner, R., Meisinger, C., Pfanner, N. (2008) Multiple pathways for sorting mitochondrial precursor proteins. EMBO J 9(1): 42-49.〕 Both Sam35 and Sam37 are located on the cytosolic face of the SAM complex are peripheral membrane proteins that are not essential for survival.〔Chan, N.C, and Lithgow, T. (2008) The Peripheral Membrane Subunits of the SAM Complex Function Codependently in Mitochondrial Outer Membrane Biogenesis. Mol. Biol. Cell 19(1): 126-136〕 Sam35 is believed to bind to substrate proteins, while Sam37 acts after Sam35 to stimulate release of the substrate protein from the SAM complex.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「sorting and assembly machinery」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|